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Article

Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection.

PLoS neglected tropical diseases - 1 Apr 2020

Addetia Amin, Tantalo Lauren C, Lin Michelle J, Xie Hong, Huang Meei-Li, Marra Christina M, Greninger Alexander L

Abstract excerpt

Developing a vaccine against Treponema pallidum subspecies pallidum, the causative agent of syphilis, remains a public health priority. Syphilis vaccine design efforts have been complicated by lack of an in vitro T. pallidum culture system, prolific antigenic variation in outer membrane protein TprK, and lack of functional annotation for nearly half of the genes. Understanding the genetic basis of T. pallidum...

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Identifiers

PMID: 32251462
DOI: 10.1371/journal.pntd.0007921
PMCID: PMC7162541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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