Article
Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection.
Molecular microbiology - 1 Jun 2004
Centurion-Lara Arturo, LaFond Rebecca E, Hevner Karin, Godornes Charmie, Molini Barbara J, Van Voorhis Wesley C, Lukehart Sheila A
Abstract excerpt
The tprK gene sequence of Treponema pallidum subspecies pallidum (T. pallidum) is heterogeneous within and among isolates. Heterogeneity in the tprK open reading frame is localized in seven discrete variable (V) regions, and variability results from apparent base changes, insertions or deletions. The TprK V regions are the focus of anti-TprK antibodies arising during infection. To test our hypothesis that V...
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