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MED19 alters AR occupancy and gene expression in prostate cancer cells, driving MAOA expression and growth under low androgen

2019-11-27

Abstract excerpt

Androgen deprivation therapy (ADT) is a mainstay of prostate cancer treatment, given the dependence of prostate cells on androgen and the androgen receptor (AR). However, tumors become ADT-resistant, and there is a need to understand the mechanism. One possible mechanism is the upregulation of AR co-regulators, although only a handful have been definitively linked to disease. We previously identified the Mediator...

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Literature Corpus work
61f37c6f-e2f2-56db-ad09-d83e8da3b6c5
DOI
10.1101/857235
Open publication

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MED19 alters AR occupancy and gene expression in prostate cancer cells, driving MAOA expression and growth under low androgenDOI 10.1101/857235
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