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CDK19 and CDK8 Mediator kinases drive androgen-independent <i>in vivo</i> growth of castration-resistant prostate cancer

2023-08-11

Abstract excerpt

Castration-resistant prostate cancer (CRPC) remains incurable due to its high plasticity. We found that Mediator kinases CDK8 and CDK19, pleiotropic regulators of transcriptional reprogramming, are differentially affected by androgen, which downregulates CDK8 and upregulates CDK19. Accordingly, expression of CDK8 decreases while CDK19 increases during prostate carcinogenesis, but both CDK19 and CDK8 are upregulate...

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Literature Corpus work
0116dd46-2eeb-5412-9566-e7f928ef4b4e
DOI
10.1101/2023.08.08.552491
Open publication

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CDK19 and CDK8 Mediator kinases drive androgen-independent <i>in vivo</i> growth of castration-resistant prostate cancerDOI 10.1101/2023.08.08.552491
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