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The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer

21 Dec 2021

Abstract excerpt

Neuroendocrine (NE) prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (PCa) arising either de novo or from transdifferentiated prostate adenocarcinoma following androgen deprivation therapy (ADT). Extensive computational analysis has identified a high degree of association between the long noncoding RNA (lncRNA) H19 and NEPC, with the longest isoform highly expressed in NEPC. H19...

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PMID: 34934057
DOI: 10.1038/s41467-021-26901-9

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