Article

DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases

2024-01-02

Abstract excerpt

Current SARS-CoV-2 vaccines have demonstrated robust induction of neutralizing antibodies and CD4+ T cell activation, however CD8+ responses are variable, and the duration of immunity and protection against variants are limited. Here we repurposed our DNA origami vaccine nanotechnology, DoriVac, for targeting infectious viruses, namely SARS-CoV-2, HIV, and Ebola. The DNA origami nanoparticle, conjugated with infec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc97916d-ff1e-503d-8052-fd3186a6151b
DOI: 10.1101/2023.12.29.573647

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseasesDOI 10.1101/2023.12.29.573647Read

DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune responseSemantic proximity Read

Next‐Generation Vaccines: Nanovaccines in the Fight against SARS‐CoV‐2 Virus and beyond SARS‐CoV‐2Semantic proximity Read

Nanoparticle-Conjugated TLR9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 VaccinesSemantic proximity Read

Engineering Versatile Two-Dimensional Nanobody-Origami Architectures for Enhanced Antiviral ActivitySemantic proximity Read

Cellular immune breadth of an Omicron-specific, self-amplifying monovalent mRNA vaccine booster for COVID-19Semantic proximity Read

Circular RNA Vaccines against SARS-CoV-2 and Emerging VariantsSemantic proximity Read

Eliciting B cell immunity against infectious diseases using nanovaccines.Semantic proximity Read

DENV Peptides Delivered as Spherical Nucleic Acid Constructs Enhance Antigen Presentation and Immunogenicity in vitro and in vivoSemantic proximity Read

DNA origami vaccines program antigen-focused germinal centersSemantic proximity Read

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drive rapid and potent immunogenicity capable of single-dose protectionSemantic proximity Read

Rapid development of a synthetic DNA vaccine for COVID-19Semantic proximity Read

In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive ImmunitySemantic proximity Read