Article

Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation

2025-01-31

Abstract excerpt

During productive transcription elongation, the speed of RNA polymerase II (Pol II) is highly dynamic within individual genes and varies between different genes 1,2 . Unregulated rapid transcription elongation can lead to detrimental consequences such as transcription-replication collisions, altered alternative splicing patterns, and genome instability 1–7 . Therefore, elongating Pol II requires mechanisms to sl...

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Literature Corpus work: 61ad55b4-a567-5a2b-9b5d-e077605aa062
DOI: 10.1101/2025.01.29.635449

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