Article

Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity

2025-07-05

Abstract excerpt

The unfolded protein response sensor PERK exists in haplotypes A and B. PERK-B confers increased risk for tauopathies like progressive supranuclear palsy (PSP), but the mechanisms distinguishing its function from PERK-A and contributing to its association with tauopathy remain unknown. Here, we developed a controlled cellular model for a pair-wise comparison of the two PERK haplotypes, finding their UPR functions...

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Literature Corpus work: a872c537-4960-5150-8c23-d9e6c891ce07
DOI: 10.1101/2025.06.30.662315

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