Article

Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

2024-06-23

Abstract excerpt

Asthenoteratozoospermia, a prevalent cause of male infertility, lacks a well-defined etiology. DNAH12 is a special dynein featured by the absence of a microtubule-binding domain, however, its functions in spermatogenesis remain largely unknown. Through comprehensive genetic analyses involving whole-exome sequencing and subsequent Sanger sequencing on infertile patients and fertile controls from six distinct famili...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6154976d-006d-5d11-9d3b-3136aae0196a
DOI: 10.1101/2024.06.20.599934

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and miceDOI 10.1101/2024.06.20.599934Read

Association of novel DNAH11 variants with asthenoteratozoospermia lead to male infertilitySemantic proximity Read

Further evidence from DNAH12 supports favorable fertility outcomes of infertile males with dynein axonemal heavy chain gene family variantsSemantic proximity Read

DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and miceSemantic proximity Read

Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure.Semantic proximity Read

Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.Semantic proximity Read

DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.Semantic proximity Read

Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella (MMAF) and ICSI outcomesSemantic proximity Read

Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.Semantic proximity Read

Loss of function mutation in DNAH7 induces male infertility associated with abnormalities of the sperm flagella and mitochondria in human.Semantic proximity Read

Genetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and MiceSemantic proximity Read

Homozygous mutation in DNALI1 leads to asthenoteratozoospermia by affecting the inner dynein arms.Semantic proximity Read

Bi-allelic variants in DNAH10 cause asthenoteratozoospermia and male infertility.Semantic proximity Read