Article

DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

2024-02-21

Abstract excerpt

Axonemal protein complexes, including the outer and inner dynein arms (ODA/IDA), are highly ordered structures of the sperm flagella that drive sperm motility. Deficiencies in several axonemal proteins have been associated with male infertility, which is characterized by asthenozoospermia or asthenoteratozoospermia. Dynein axonemal heavy chain 3 (DNAH3) resides in the IDA and is highly expressed in the testis. How...

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Literature Corpus work: df361c5e-a395-5f29-9c96-7df44a547bd5
DOI: 10.1101/2024.02.19.580977

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