Article
DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.
Cell death & disease - 15 Feb 2023
Wu Huan, Liu Yiyuan, Li Yuqian, Li Kuokuo, Xu Chuan, Gao Yang, Lv Mingrong, Guo Rui, Xu Yuping, Zhou Ping, Wei Zhaolian, Hua Rong, He Xiaojin, Cao Yunxia
Abstract excerpt
The axonemal dynein arms (outer (ODA) and inner dynein arms (IDAs)) are multiprotein structures organized by light, intermediate, light intermediate (LIC), and heavy chain proteins. They hydrolyze ATP to promote ciliary and flagellar movement. Till now, a variety of dynein protein deficiencies have been linked with asthenospermia (ASZ), highlighting the significance of these structures in human sperm motility....
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