Article
Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.
American journal of human genetics - 5 Aug 2021
Tu Chaofeng, Cong Jiangshan, Zhang Qianjun, He Xiaojin, Zheng Rui, Yang Xiaoxuan, Gao Yang, Wu Huan, Lv Mingrong, Gu Yayun, Lu Shuai, Liu Chunyu, Tian Shixiong, Meng Lanlan, Wang Weili, Tan Chen, Nie Hongchuan, Li Dongyan, Zhang Huan, Gong Fei, Hu Liang, Lu Guangxiu, Xu Wenming, Lin Ge, Zhang Feng, Cao Yunxia, Tan Yue-Qiu
Abstract excerpt
Multiple morphological abnormalities of the sperm flagella (MMAF)-induced asthenoteratozoospermia is a common cause of male infertility. Previous studies have identified several MMAF-associated genes, highlighting the condition's genetic heterogeneity. To further define the genetic causes underlying MMAF, we performed whole-exome sequencing in a cohort of 643 Chinese MMAF-affected men. Bi-allelic DNAH10 variants...
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