Article
Bi-allelic variants in DNAH10 cause asthenoteratozoospermia and male infertility.
Journal of assisted reproduction and genetics - 1 Jan 2022
Li Kuokuo, Wang Guanxiong, Lv Mingrong, Wang Jieyu, Gao Yang, Tang Fei, Xu Chuan, Yang Wen, Yu Hui, Shao Zhongmei, Geng Hao, Tan Qing, Shen Qunshan, Tang Dongdong, Ni Xiaoqing, Wang Tianjuan, Song Bing, Wu Huan, Huo Ran, Zhang Zhiguo, Xu Yuping, Zhou Ping, Tao Fangbiao, Wei Zhaolian, He Xiaojin, Cao Yunxia
Abstract excerpt
PURPOSE: Multiple morphological abnormalities in the sperm flagella (MMAF) comprise a severe phenotype of asthenoteratozoospermia with reduced or absent spermatozoa motility. Whereas dozens of candidate pathogenic genes for MMAF have been identified, the genetic cause in a large proportion of patients is unknown. We attempted to identify novel genetic explanations for MMAF. METHODS: We performed whole-exome...
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