Article
Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure.
Acta biochimica et biophysica Sinica - 12 Oct 2021
Wei Xiaoli, Sha Yanwei, Wei Zijie, Zhu Xingshen, He Fengming, Zhang Xiaoya, Liu Wensheng, Wang Yifeng, Lu Zhongxian
Abstract excerpt
Asthenozoospermia is the most common cause of male infertility. Dynein protein arms play a crucial role in the motility of both the cilia and flagella, and defects in these proteins generally impair the axoneme structure and cause primary ciliary dyskinesia. But relatively little is known about the influence of dynein protein arm defects on sperm flagella function. Here, we recruited 85 infertile patients with...
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