Article
Homozygous mutation in DNALI1 leads to asthenoteratozoospermia by affecting the inner dynein arms.
Frontiers in endocrinology - 1 Jan 2022
Sha Yanwei, Liu Wensheng, Nie Hua, Han Lu, Ma Chunjie, Zhang Xiaoya, Xiao Ziyi, Qin Weibing, Jiang Xiaoming, Wei Xiaoli
Abstract excerpt
Asthenozoospermia is the most common cause of male infertility. Dynein protein arms play a crucial role in the motility of sperm flagella and defects in these proteins generally impair the axoneme structure and affect sperm flagella function. In this study, we performed whole exome sequencing for a cohort of 126 infertile patients with asthenozoospermia and identified homozygous DNALI1 mutation in one patient...
Topics
Join the communities discussing this publication.