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Loss of function mutation in DNAH7 induces male infertility associated with abnormalities of the sperm flagella and mitochondria in human.

Clinical genetics - 1 Aug 2022

Gao Yang, Liu Liting, Shen Qunshan, Fu Feifei, Xu Chuan, Geng Hao, Lv Mingrong, Li Kuokuo, Tang Dongdong, Song Bing, Wu Huan, Xu Yuping, Zhang Ying, Tao Fangbiao, Zhou Ping, Wei Zhaolian, He Xiaojin, Cao Yunxia

Abstract excerpt

Male infertility is an increasingly serious health problem affecting couples of reproductive age. Mutations in axoneme-associated genes cause male infertility. Dynein arm proteins are essential in sustaining normal axonemes and promote flagellar motility. However, the function of DNAH7 in male fertility in vivo remains unclear. Herein, we showed that DNAH7 disruption in humans results in male infertility, which...

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Dyneins
Infertility, Male
Loss of Function Mutation
Mitochondria
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35543642
DOI: 10.1111/cge.14146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Loss of function mutation in DNAH7 induces male infertility associated with abnormalities of the sperm flagella and mitochondria in human.PMID 35543642Read ↗

Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and miceSemantic proximity Read ↗

Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.Semantic proximity Read ↗

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