Article

A conserved metabolic signature associated with response to fast-acting antimalarial agents

2022-10-03

Abstract excerpt

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads with different speed of kill profiles being developed by the Novartis Institute of Tropical Diseases (NITD). Time-resolv...

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Literature Corpus work: 614c4c48-ebf7-5e73-80a1-3284e02a2b5a
DOI: 10.1101/2022.10.03.510714

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