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Metabolomic-Based Strategies for Anti-Parasite Drug Discovery

3 Oct 2014

Abstract excerpt

Metabolomics-based studies are proving of great utility in the analysis of modes of action (MOAs) and resistance mechanisms of drugs in parasitic protozoa. They have helped to determine the MOA of eflornithine, half of the gold standard combination therapy in use against human African trypanosomiasis (HAT), as well as the mechanism of resistance to this drug. In Leishmania, metabolomics has also given insight...

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PMID: 25281738
DOI: 10.1177/1087057114551519

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