Article

Human gut metagenomes encode diverse GH156 sialidases

2022-06-28

Abstract excerpt

The intestinal lining is protected by a mucous barrier composed predominantly of complex carbohydrates. Gut microbes employ an array of glycoside hydrolases (GHs) to liberate mucosal sugars as a nutrient source to facilitate host colonization. Intensive catabolism of mucosal glycans, however, may contribute to barrier erosion, pathogen encroachment and inflammation. Sialic acid is an acidic sugar featured at termi...

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Literature Corpus work: e3b47c7b-4163-58a6-bd47-e4a26f968dce
DOI: 10.1101/2022.06.28.497753

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