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Degradation of mucin <i>O</i> -glycans by a human gut symbiont requires a complex enzyme repertoire and promotes colonization

2026-03-26

Abstract excerpt

<h4>Summary</h4> Secreted mucins are the major component of the mucus layer that protects intestinal epithelial surfaces by blocking excessive interactions with the microbiota. Mucins are complex glycoproteins decorated with over 100 different O -glycans. Some bacteria can utilize mucins and excessive degradation has been associated with disruption of the mucus barrier and inflammation. Despite the importance of...

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Literature Corpus work
9c3bbd59-5f27-58b0-9eef-e49039b7fd0a
DOI
10.64898/2026.03.26.714468
Open publication

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