Article

Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease

2023-11-07

Abstract excerpt

<title>Abstract</title> <p><italic>HTRA1</italic> has emerged as a major risk gene for stroke and cerebral small vessel disease with both rare and common variants contributing to disease risk. However, the precise mechanisms mediating this risk remain largely unknown as does the full spectrum of phenotypes associated with genetic variation in <italic>HTRA1</italic> in the general population. Using a family-histor...

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Literature Corpus work: 33136dfb-dd74-523b-afd6-a5fcb6096a8c
DOI: 10.21203/rs.3.rs-3523612/v1

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