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Article

Rare Variants in HTRA1, SGTB, and RBM12 Confer Risk of Atherosclerotic Cardiovascular Disease Independent of Traditional Cardiovascular Risk Factors.

Circulation. Genomic and precision medicine - 1 Dec 2025

Lockhart Sam M, Puri Anuradhika, Zhao Yajie, Saudek Vladimir, Gardner Eugene J, Kentistou Katherine A, Lam Brian Y H, Day Felix R, O'Rahilly Stephen, Perry John R B, Ong Ken K, Jackrel Meredith E

Abstract excerpt

BACKGROUND: Atherosclerosis is a pathophysiological process common to a range of cardiovascular diseases. We reasoned that considering clinical presentations of atherosclerosis across the coronary, peripheral, and cerebrovasculature as a single entity would enhance statistical power to identify rare genetic variation driving pathological processes across multiple vascular beds. METHODS: We performed an exome-wide...

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Source

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Identifiers

PMID: 41190437
DOI: 10.1161/CIRCGEN.125.005233
PMCID: PMC7618418

Genes

HTRA1
RBM12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Rare Variants in HTRA1, SGTB, and RBM12 Confer Risk of Atherosclerotic Cardiovascular Disease Independent of Traditional Cardiovascular Risk Factors.PMID 41190437Read ↗

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