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Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities

6 Jul 2021

Abstract excerpt

White matter hyperintensities (WMH) are among the most common radiological abnormalities in the ageing population and an established risk factor for stroke and dementia. While common variant association studies have revealed multiple genetic loci with an influence on their volume, the contribution of rare variants to the WMH burden in the general population remains largely unexplored. We conducted a comprehensive...

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PMID: 34626176
DOI: 10.1093/brain/awab253

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