Multiple Machine Learning Models, Molecular Subtyping and Singlecell Analysis Identify PANoptosis-related Core Genes and their Association with Subtypes in Crohn’s Disease

Abstract excerpt

BACKGROUND: PANoptosis plays an important role in many inflammatory diseases. However, there are no reports on the association between PANoptosis and CD. MATERIALS AND METHODS: This study used five machine learning algorithms - least absolute shrinkage and selection operator, support vector machine, random forest, decision tree and Gaussian mixture models - to construct CD's PANoptosis signature. Unsupervised...

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