Back to search

Article

IFNγ and TNFα Driven IRF1-Caspase 8 Dependent PANoptosis Promotes Keratinocyte Death in Psoriasis Independent of ZBP1

2026-05-19

Abstract excerpt

<title>Abstract</title> <p>Psoriasis is a chronic inflammatory skin disorder characterized by dysregulated keratinocyte proliferation, differentiation, and immune activation. While aberrant immune signaling is well established, the contribution of inflammatory cell death pathways remains incompletely understood. Here, we identify PANoptosis, an integrated form of programmed cell death encompassing pyroptosis, apo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0f23b1c5-d8fb-58eb-9860-217dde8d63b2
DOI
10.21203/rs.3.rs-9531266/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
IFNγ and TNFα Driven IRF1-Caspase 8 Dependent PANoptosis Promotes Keratinocyte Death in Psoriasis Independent of ZBP1DOI 10.21203/rs.3.rs-9531266/v1
Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammationSemantic proximity
Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncologySemantic proximity
Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammationSemantic proximity
Role of Pyroptosis and Immune Infiltration in Keloids: Novel Insights from Bioinformatics AnalysesSemantic proximity
Bioinformatics Analysis Identifies Potential PANoptosis Key Gene in Psoriasis with Single-cell validation and screening of related natural drugSemantic proximity
Death-Associated Protein Kinase 1 Dampens Keratinocyte Necroptosis and Expression of Inflammatory Genes in Lichen PlanusSemantic proximity
Modulation of Epidermal Transcription Circuits in Psoriasis: New Links between Inflammation and HyperproliferationSemantic proximity
The NLRP1 Inflammasome in Human Skin and BeyondSemantic proximity
A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9 <sup>+</sup> Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive AutoimmunitySemantic proximity
PANoptosis in cancer, the triangle of cell deathSemantic proximity
RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene SignatureSemantic proximity
Defining critical roles for ZBP1 in PANoptosis utilizing a novel genetic tool for disease modeling and therapeutic developmentSemantic proximity
Select a neighboring publication to make it the new centre.