Article

Single Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis

2020-03-10

Abstract excerpt

Cystic fibrosis (CF) is a life-shortening multisystem hereditary disease caused by abnormal chloride transport. CF lung disease is driven by innate immune dysfunction that perpetuates inflammation. The airways provide a window into CF pathogenesis, as immune cells display exaggerated inflammatory responses and impaired phagocytic function, contributing to tissue injury. In order to define the transcriptional profi...

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Literature Corpus work: 61361146-bd4d-5f96-9897-d817756b3f48
DOI: 10.1101/2020.03.06.20032292

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