Article

<i>CFTR</i>-mediated monocyte-macrophage dysfunction revealed by cystic fibrosis proband- parent comparisons

2021-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Cystic fibrosis (CF) is an inherited disorder caused by biallelic mutations of the cystic fibrosis transmembrane conductance regulator gene ( CFTR ). Converging lines of evidence suggest that CF carriers with only one defective CFTR copy are at increased risk for CF-related conditions and pulmonary infections, but the molecular mechanisms underpinning this effect remain unknown. Here, we performe...

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Literature Corpus work: 2da94616-bbd0-5d4f-a896-1b45648c73e7
DOI: 10.1101/2021.06.30.21259182

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