Article
Single-cell transcriptomic analysis reveals key immune cell phenotypes in the lungs of patients with asthma exacerbation.
The Journal of allergy and clinical immunology - 1 Mar 2021
Li Hui, Wang Huaqi, Sokulsky Leon, Liu Shaoxia, Yang Rui, Liu Xiaojie, Zhou Lujia, Li Juan, Huang Chun, Li Fangfang, Lei Xu, Jia Hongxia, Cheng Jiuling, Li Fuguang, Yang Ming, Zhang Guojun
Abstract excerpt
BACKGROUND: Asthma exacerbations are associated with heightened asthma symptoms, which can result in hospitalization in severe cases. However, the molecular immunologic processes that determine the course of an exacerbation remain poorly understood, impeding the progression of development of effective therapies. OBJECTIVE: Our aim was to identify candidate genes that are strongly associated with asthma...
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