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Article

CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages.

Science advances - 26 May 2023

Gillan Jonathan L, Chokshi Mithil, Hardisty Gareth R, Clohisey Hendry Sara, Prasca-Chamorro Daniel, Robinson Nicola J, Lasota Benjamin, Clark Richard, Murphy Lee, Whyte Moira K B, Baillie J Kenneth, Davidson Donald J, Bao Gang, Gray Robert D

Abstract excerpt

An intense, nonresolving airway inflammatory response leads to destructive lung disease in cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet governing the progression of CF lung disease, but the underlying mechanisms are not fully understood. We used 5' end centered transcriptome sequencing to profile P. aeruginosa LPS-activated human CF macrophages, showing that CF and non-CF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37235648
DOI: 10.1126/sciadv.adg5128
PMCID: PMC10219589

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