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Article

Evidence for altered immune-structural cell crosstalk in cystic fibrosis revealed by single cell transcriptomics

12 Feb 2025

Abstract excerpt

Background Chronic pulmonary inflammation strongly contributes to respiratory failure and mortality in patients with cystic fibrosis (pwCF). Effective anti-microbial immunity and maintaining lung homeostasis require continuous structural-immune cell communication. Whether and how this crosstalk is altered in CF remains poorly understood, obscuring potential new angles for therapy development to restore airway...

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PMID: 39947933
DOI: 10.1016/j.jcf.2025.01.016

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