Article

Acute Myeloid Leukemia with deletion 5q is an epigenetically distinct subgroup defined by heterozygous loss of <i>KDM3B</i>

2024-11-15

Abstract excerpt

Acute myeloid leukemia (AML) is a hematological malignancy characterized by a block in differentiation and accelerated proliferation of myeloid progenitor cells. Genes encoding for epigenetic regulators are among the most frequent targets for mutations and structural variations in AML, giving rise to profound epigenetic heterogeneity between and within tumors. Deletions of chromosome 5q [del(5q)] are among the mos...

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Literature Corpus work: 6134338c-fb9a-5f30-8ef1-ee043b9f525d
DOI: 10.1101/2024.11.13.623380

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