Article
Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Apr 2012
Jerez Andres, Gondek Lukasz P, Jankowska Anna M, Makishima Hideki, Przychodzen Bartlomiej, Tiu Ramon V, O'Keefe Christine L, Mohamedali Azim M, Batista Denise, Sekeres Mikkael A, McDevitt Michael A, Mufti Ghulam J, Maciejewski Jaroslaw P
Abstract excerpt
PURPOSE: Interstitial deletions of chromosome 5q are common in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), pointing toward the pathogenic role of this region in disease phenotype and clonal evolution. The higher level of resolution of single-nucleotide polymorphism array (SNP-A) karyotyping may be used to find cryptic abnormalities and to precisely define the topographic features of the...
Topics
- Age Distribution
- Aged
- Anemia, Macrocytic
- Chromosome Deletion
- Chromosomes, Human, Pair 5
- Cohort Studies
- Female
- Genetic Predisposition to Disease
- Genomics