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The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes

12 Jan 2023

Abstract excerpt

Epigenetic regulators are frequently mutated in hematological malignancies including acute myeloid leukemia (AML). Thus, the identification and characterization of novel epigenetic drivers affecting AML biology holds potential to improve our basic understanding of AML and to uncover novel options for therapeutic intervention. To identify novel tumor suppressive epigenetic regulators in AML, we performed an in...

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Share to Acute Myeloid Leukemia Research
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PMID: 36631623
DOI: 10.1038/s41375-023-01810-6

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