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Article

Microhomology-mediated tandem duplication is a conserved mechanism of genomic variation with implications for human disease.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2026

Wei Xianfang, Gong Wanxin, Zheng Yifan, Zhang Jing, Wei Xianyuan, Peng Chen, He Xiangwei, Jiang Chao

Abstract excerpt

Tandem repeats are highly mutable genomic elements with significant functional consequences, yet the mechanisms underlying their evolutionary origin remain unclear. One proposed mechanism is microhomology-mediated tandem duplication (MTD), in which single-copy DNA segments flanked by microhomology undergo duplication and may subsequently expand. Although MTD was first described in Schizosaccharomyces pombe, its...

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Identifiers

PMID: 42085162
DOI: 10.1073/pnas.2606747123
PMCID: PMC13167724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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