Article

Break-induced replication underlies formation of inverted triplications and generates unexpected diversity in haplotype structures

2023-10-03

Abstract excerpt

<h4>Background</h4> The duplication-triplication/inverted-duplication (DUP-TRP/INV-DUP) structure is a type of complex genomic rearrangement (CGR) hypothesized to result from replicative repair of DNA due to replication fork collapse. It is often mediated by a pair of inverted low-copy repeats (LCR) followed by iterative template switches resulting in at least two breakpoint junctions in cis . Although it has be...

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Literature Corpus work: 6b74f93a-bbeb-57a9-850b-3c934ea157c0
DOI: 10.1101/2023.10.02.560172

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