Article

Gut delivery of pentameric GLP-1 using genetically engineered <i>Bacillus subtilis</i>

2025-10-07

Abstract excerpt

Glucagon-like peptide-1 (GLP-1) receptor agonists and GLP-1 analogs are widely used for type 2 diabetes and weight management, but current approaches can be limited by manufacturing complexity, cost, formulation requirements, and the need for repeated administration. Living microbial delivery systems offer a potential strategy for sustained gastrointestinal production of therapeutic peptides, yet achieving stable...

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Literature Corpus work: 61223ad7-7776-5931-9411-99595ea25ae7
DOI: 10.1101/2025.10.07.680898

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