Article

Physiologically relevant Multi-Omics Flux Analysis Reveals Metabolic Mechanisms of drug-Induced Liver Toxicity

2026-06-12

Abstract excerpt

<title>Abstract</title> <p>Adverse drug reactions remain a major challenge in drug development and clinical practice. Biomarkers for drug-induced liver injury reflect evolving injury rather than enabling early detection or mechanistic insight before leakage occurs. Physiologically relevant assays that also capture dynamic human drug exposure may close that gap. Here, we present a systems pharmacology framework in...

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Literature Corpus work: 7fbb22ed-53aa-5fe3-9ea7-6cccc113edbf
DOI: 10.21203/rs.3.rs-9947061/v1

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Physiologically relevant Multi-Omics Flux Analysis Reveals Metabolic Mechanisms of drug-Induced Liver ToxicityDOI 10.21203/rs.3.rs-9947061/v1Read

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