Article

New C3H <i>Kit</i> <sup>N824K/WT</sup> cancer mouse model develops late-onset malignant mammary tumors with high penetrance

2022-08-23

Abstract excerpt

Gastro-intestinal stromal tumors and acute myeloid leukemia induced by activating stem cell factor receptor tyrosine kinase (KIT) mutations are highly malignant. Less clear is the role of KIT-mutations in the context of breast cancer. Treatment success of KIT-induced cancers is still unsatisfactory because of primary or secondary resistance to therapy. Mouse models offer essential platforms for studies on molecula...

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Literature Corpus work: 5970883f-1052-5ce5-855b-ed576b49494d
DOI: 10.1101/2022.08.23.504938

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