Article

ATP-citrate lyase as a therapeutic target in chronic kidney disease: a Mendelian Randomization analysis

2021-10-11

Abstract excerpt

<h4>Background</h4> ATP-citrate lyase (ACLY) inhibition is a promising therapeutic target for dyslipidemia, atherosclerotic cardiovascular disease, non-alcoholic steatohepatitis, and metabolic syndrome. Genetic analysis of its role in chronic kidney disease (CKD) has not been performed. <h4>Methods</h4> We constructed a genetic instrument by selecting variants associated with ACLY expression level in the expressio...

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Literature Corpus work: 60dd6786-2ef9-53df-8a41-93bd51eb6c7e
DOI: 10.1101/2021.10.07.21264710

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