Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ACLY and CKD: A Mendelian Randomization Analysis

21 Apr 2022

Abstract excerpt

Introduction Adenosine triphosphate-citrate lyase (ACLY) inhibition is a therapeutic strategy under investigation for atherosclerotic cardiovascular disease, nonalcoholic steatohepatitis, and metabolic syndrome. Mouse models suggest that ACLY inhibition could reduce inflammation and kidney fibrosis. Genetic analysis of ACLY in chronic kidney disease (CKD) has not been performed. Methods We constructed a genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Disease and Adiposity
Share to Chronic Kidney Disease and Diabetes
Share to Renin-Angiotensin System Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35812273
DOI: 10.1016/j.ekir.2022.04.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ACLY and CKD: A Mendelian Randomization AnalysisPMID 35812273Read ↗

ATP-citrate lyase as a therapeutic target in chronic kidney disease: a Mendelian Randomization analysisSemantic proximity Read ↗

Mendelian Randomization Study of ACLY and Cardiovascular DiseaseSemantic proximity Read ↗

Effects of ACLY Inhibition on Body Weight Distribution: A Drug Target Mendelian Randomization Study.Semantic proximity Read ↗

HDL Cholesterol, LDL Cholesterol, and Triglycerides as Risk Factors for CKD: A Mendelian Randomization Study.Semantic proximity Read ↗

The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analysesSemantic proximity Read ↗

Deciphering the Effect of High-Density Lipoprotein Cholesterol on Renal Function: a Mendelian Randomization StudySemantic proximity Read ↗

Causal effect between total cholesterol and HDL cholesterol as risk factors for chronic kidney disease: a mendelian randomization studySemantic proximity Read ↗

The citrate transporter SLC13A5 as a therapeutic target for kidney disease: evidence from Mendelian randomization to inform drug developmentSemantic proximity Read ↗

Lipid-lowering drugs and risk of rapid renal function decline: a mendelian randomization study.Semantic proximity Read ↗

Lipid-Lowering Drugs and Risk of Rapid Renal Function Decline: A Mendelian Randomization StudySemantic proximity Read ↗

Bidirectional Mendelian randomization of leukocyte counts, renal function, and Lipocalin-2 Levels: disentangling the genetic links, causal pathways and cardiovascular outcomes.Semantic proximity Read ↗

Inactive matrix Gla protein is causally related to adverse health outcomes: a Mendelian randomization study in a Flemish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.