Article
Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study.
Journal of the American College of Cardiology - 30 Aug 2016
van der Laan Sander W, Fall Tove, Soumaré Aicha, Teumer Alexander, Sedaghat Sanaz, Baumert Jens, Zabaneh Delilah, van Setten Jessica, Isgum Ivana, Galesloot Tessel E, Arpegård Johannes, Amouyel Philippe, Trompet Stella, Waldenberger Melanie, Dörr Marcus, Magnusson Patrik K, Giedraitis Vilmantas, Larsson Anders, Morris Andrew P, Felix Janine F, Morrison Alanna C, Franceschini Nora, Bis Joshua C, Kavousi Maryam, O'Donnell Christopher, Drenos Fotios, Tragante Vinicius, Munroe Patricia B, Malik Rainer, Dichgans Martin, Worrall Bradford B, Erdmann Jeanette, Nelson Christopher P, Samani Nilesh J, Schunkert Heribert, Marchini Jonathan, Patel Riyaz S, Hingorani Aroon D, Lind Lars, Pedersen Nancy L, de Graaf Jacqueline, Kiemeney Lambertus A L M, Baumeister Sebastian E, Franco Oscar H, Hofman Albert, Uitterlinden André G, Koenig Wolfgang, Meisinger Christa, Peters Annette, Thorand Barbara, Jukema J Wouter, Eriksen Bjørn Odvar, Toft Ingrid, Wilsgaard Tom, Onland-Moret N Charlotte, van der Schouw Yvonne T, Debette Stéphanie, Kumari Meena, Svensson Per, van der Harst Pim, Kivimaki Mika, Keating Brendan J, Sattar Naveed, Dehghan Abbas, Reiner Alex P, Ingelsson Erik, den Ruijter Hester M, de Bakker Paul I W, Pasterkamp Gerard, Ärnlöv Johan, Holmes Michael V, Asselbergs Folkert W
Abstract excerpt
BACKGROUND: Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation. OBJECTIVES: The aim of this study was to use Mendelian randomization to investigate whether...
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