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Clinical and Metabolic Effects of ATP Citrate Lyase Inhibition with Bempedoic Acid in Patients with Chronic Coronary Syndrome: A Real-World Translational Study

2025-12-30

Abstract excerpt

<h4>Background: </h4> Hepatic cholesterol synthesis inhibition is a cornerstone of atherosclerotic cardiovascular disease (ASCVD) prevention. Despite intensive lipid-lowering therapy, many very-high-risk patients with chronic coronary syndrome (CCS) fail to achieve recommended LDL-C targets. Bempedoic acid (BA), a liver-activated ATP citrate lyase (ACLY) inhibitor, suppresses cholesterol biosynthesis upstream of H...

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Literature Corpus work
3af18754-e4ad-5ff7-aba6-a4176028de02
DOI
10.20944/preprints202512.2633.v1
Open publication

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Clinical and Metabolic Effects of ATP Citrate Lyase Inhibition with Bempedoic Acid in Patients with Chronic Coronary Syndrome: A Real-World Translational StudyDOI 10.20944/preprints202512.2633.v1
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