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The citrate transporter SLC13A5 as a therapeutic target for kidney disease: evidence from Mendelian randomization to inform drug development

2023-08-29

Abstract excerpt

<h4>Background</h4> Solute carrier family 13 member 5 (SLC13A5) is a Na -coupled citrate co-transporter that mediates the entry of extracellular citrate into the cytosol. SLC13A5 inhibition has been proposed as a therapeutic target for reducing progression of kidney disease via its effects on citrate metabolism. However, evidence of its efficacy in humans is limited. The aim of this study was to leverage the Mende...

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Literature Corpus work
1ad692e8-da7b-5533-b2c5-0577ae6b1871
DOI
10.1101/2023.08.29.23294760
Open publication

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The citrate transporter SLC13A5 as a therapeutic target for kidney disease: evidence from Mendelian randomization to inform drug developmentDOI 10.1101/2023.08.29.23294760
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