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A Focused Small-Molecule Screen Identifies PHA-680626 as an Amphosteric Inhibitor Disrupting the Interaction between Aurora-A and N-Myc

2021-03-10

Abstract excerpt

<h4>ABSTRACT</h4> Neuroblastoma is a severe childhood disease, accounting for ~10% of all infant cancers. The amplification of the MYCN gene, coding for the N-Myc transcriptional factor, is an essential marker correlated with tumor progression and poor prognosis. In neuroblastoma cells, the mitotic kinase Aurora-A (AURKA), also frequently overexpressed in cancer, prevents N-Myc degradation, by directly binding to...

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Literature Corpus work: 60d29676-4d30-59be-8be7-5272ed966c1c
DOI: 10.1101/2021.03.10.433854

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