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Article

Targeting of the MYCN Protein with Small Molecule c-MYC Inhibitors

23 May 2014

Abstract excerpt

Members of the MYC family are the most frequently deregulated oncogenes in human cancer and are often correlated with aggressive disease and/or poorly differentiated tumors. Since patients with MYCN-amplified neuroblastoma have a poor prognosis, targeting MYCN using small molecule inhibitors could represent a promising therapeutic approach. We have previously demonstrated that the small molecule 10058-F4, known...

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PMID: 24859015
DOI: 10.1371/journal.pone.0097285

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Targeting of the MYCN Protein with Small Molecule c-MYC InhibitorsPMID 24859015Read ↗

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The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma CellsSemantic proximity Read ↗

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Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cellsSemantic proximity Read ↗

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