Article

A novel carcinogenic PI3Kα mutation suggesting the role of helical domain in transmitting nSH2 regulatory signals to kinase domain

2020-02-13

Abstract excerpt

<title>Abstract</title> <p>Background Mutations in PIK3CA, which encodes p110 subunit of PI3K class IA enzyme, are highly frequent in breast cancer. Here, we aimed to probe mutations in exon 9 of PIK3CA and computationally simulate their function. Method PCR/HRM and PCR/sequencing were used for mutation detection in 40 breast cancer specimens. The identified mutations were queried via in silico algorithms to chec...

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Literature Corpus work: 60c1d5ee-44a0-5902-bc5b-ea8ab87ab22f
DOI: 10.21203/rs.2.12981/v3

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