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Article

An integrated investigation of structural and pathway alteration caused by PIK3CA and TP53 mutations identified in cfDNA of metastatic breast cancer.

Journal of cellular biochemistry - 1 Feb 2023

R Hephzibah Cathryn, Kumar S Udhaya, R Gnanasambandan, Naayanan P Jeyaprakash, Sathiyarajeswaren P, Devi M S Shree, K Satish Srinivas, Doss C George Priya

Abstract excerpt

In peripheral blood, cell-free DNA (cfDNA) contains circulating tumor DNA (ctDNA), which indicates molecular abnormalities in metastatic breast tumor tissue. The sequencing of cfDNA of Metastatic Breast Cancer (MBC) patients allows assessment of therapy response and noninvasive treatment. In the proposed study, clinically significant alterations in PIK3CA and TP53 genes associated with MBC resulting in a missense...

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PMID: 36563059
DOI: 10.1002/jcb.30354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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