Article

Joint analysis of functional genomic data and genome-wide association studies of 18 human traits

2013-11-19

Abstract excerpt

Annotations of gene structures and regulatory elements can inform genome-wide association studies (GWAS). However, choosing the relevant annotations for interpreting an association study of a given trait remains challenging. We describe a statistical model that uses association statistics computed across the genome to identify classes of genomic element that are enriched or depleted for loci that influence a trait...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60bfa8d6-d531-51ae-8c84-13e2962a7c96
DOI: 10.1101/000752

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Joint analysis of functional genomic data and genome-wide association studies of 18 human traitsDOI 10.1101/000752Read

Joint analysis of functional genomic data and genome-wide association studies of 18 human traits.Semantic proximity Read

An integrated platform to systematically identify causal variants and genes for polygenic human traitsSemantic proximity Read

Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci.Semantic proximity Read

Partitioning heritability by functional category using GWAS summary statisticsSemantic proximity Read

Integrative analysis of 10,000 epigenomic maps across 800 samples for regulatory genomics and disease dissectionSemantic proximity Read

A sequence-based global map of regulatory activity for deciphering human geneticsSemantic proximity Read

Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits.Semantic proximity Read

Personal and population genomics of human regulatory variation.Semantic proximity Read

Comprehensive evaluation of disease- and trait-specific enrichment for eight functional elements among GWAS-identified variants.Semantic proximity Read

ANNORE: genetic fine-mapping with functional annotation.Semantic proximity Read

Regulatory variants explain much more heritability than coding variants across 11 common diseasesSemantic proximity Read

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s diseaseSemantic proximity Read