Article

Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells

2026-06-11

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dysregulated immune activation. Emerging evidence indicates that resident and infiltrating immune cells in the lung can encounter the virus early in infection and, under specific conditions, become infected ( 1, 2 ). Th...

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Literature Corpus work: 9393ebbd-93b4-5ee7-a916-a307a1b13406
DOI: 10.64898/2026.06.10.731427

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