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Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8

28 Mar 2022

Abstract excerpt

Patients infected with SARS-CoV-2 variants lacking open reading frame 8 (ORF8) have been associated with milder infection and disease outcome, but the molecular mechanism behind how this viral accessory protein mediates disease pathogenesis is not yet known. In our study, we revealed that secreted ORF8 protein mimics host IL-17 to activate IL-17 receptors A and C (IL-17RA/C) and induces a significantly stronger...

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PMID: 35343786
DOI: 10.1128/mbio.00402-22

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